' 
SCIENTIFIC SCORE
Moderately Effective
Based on 28 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.1
Supplement Facts
Serving Size: One (1) Capsule
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%+
Total Sugars
0 g
**
Incl. 0 g Added Sugars
0%+
Lactobacillus rhamnosus GG
83 mg (20 billion CFUs)
**
Inulin (Chicory root extract)
200 mg
**
Top Medical Research Studies
9
LC-STH-13 counters lupus effects
LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway.
High relevance, promising findings
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
9.5
Inulin protects against type 1 diabetes
Inulin prebiotic ameliorates type 1 diabetes dictating regulatory T cell homing via CCR4 to pancreatic islets and butyrogenic gut microbiota in murine model.
Direct investigation of inulin effects.
We explored how inulin, a type of prebiotic fiber, impacts the immune response in the context of type 1 diabetes (T1D) using a specific mouse model. Our findings showed that mice treated with inulin alongside a chemical that induces diabetes, called streptozotocin, did not develop the disease. In fact, these mice had lower blood glucose levels, reduced inflammation in their pancreas, and more balanced insulin levels compared to those not receiving inulin.
The mice that received inulin also demonstrated an interesting change in their gut health, showcasing an increase in beneficial bacteria like Bifidobacterium and Akkermansia muciniphila, as well as higher levels of butyrate, a short-chain fatty acid crucial for gut health. This improved gut microbiota seemed to support regulatory T cells, which play an important role in immune regulation.
Specifically, we noted that inulin helped recruit these regulatory T cells into the pancreas, a site critical for managing the immune response in diabetes. This recruitment depended on a specific pathway involving something known as CCR4. When we looked at mice lacking this CCR4 receptor, the beneficial effects of inulin were significantly reduced, highlighting its importance.
Overall, these findings suggest that inulin could be a promising nutritional strategy for enhancing immune health and potentially protecting against autoimmune conditions like T1D.
The mice that received inulin also demonstrated an interesting change in their gut health, showcasing an increase in beneficial bacteria like Bifidobacterium and Akkermansia muciniphila, as well as higher levels of butyrate, a short-chain fatty acid crucial for gut health. This improved gut microbiota seemed to support regulatory T cells, which play an important role in immune regulation.
Specifically, we noted that inulin helped recruit these regulatory T cells into the pancreas, a site critical for managing the immune response in diabetes. This recruitment depended on a specific pathway involving something known as CCR4. When we looked at mice lacking this CCR4 receptor, the beneficial effects of inulin were significantly reduced, highlighting its importance.
Overall, these findings suggest that inulin could be a promising nutritional strategy for enhancing immune health and potentially protecting against autoimmune conditions like T1D.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models.
Study shows viable celiac treatment potential.
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
Read More
Most Useful Reviews
8.3
Improved digestion
Good probiotics—my bowel movements improved, and my stomach no longer felt bloated. I was pleased with the results and will order again.
Read More
8
Improved flatulence
Effective ~ ~ ~ I purchased these probiotics to alleviate my flatulence and found that they helped. Feeling better now ~ ~ hee hee.
Read More
3.8
Unpleasant gastrointestinal sensation
During the intake, I experienced some unpleasant sensations in my gastrointestinal tract, which ceased after finishing the course. I'm unsure if this was related to the probiotics or merely coincidental, but I won't be ordering them again.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 28 Researches
8
9.5
Inulin protects against type 1 diabetes
Inulin prebiotic ameliorates type 1 diabetes dictating regulatory T cell homing via CCR4 to pancreatic islets and butyrogenic gut microbiota in murine model.
Direct investigation of inulin effects.
We explored how inulin, a type of prebiotic fiber, impacts the immune response in the context of type 1 diabetes (T1D) using a specific mouse model. Our findings showed that mice treated with inulin alongside a chemical that induces diabetes, called streptozotocin, did not develop the disease. In fact, these mice had lower blood glucose levels, reduced inflammation in their pancreas, and more balanced insulin levels compared to those not receiving inulin.
The mice that received inulin also demonstrated an interesting change in their gut health, showcasing an increase in beneficial bacteria like Bifidobacterium and Akkermansia muciniphila, as well as higher levels of butyrate, a short-chain fatty acid crucial for gut health. This improved gut microbiota seemed to support regulatory T cells, which play an important role in immune regulation.
Specifically, we noted that inulin helped recruit these regulatory T cells into the pancreas, a site critical for managing the immune response in diabetes. This recruitment depended on a specific pathway involving something known as CCR4. When we looked at mice lacking this CCR4 receptor, the beneficial effects of inulin were significantly reduced, highlighting its importance.
Overall, these findings suggest that inulin could be a promising nutritional strategy for enhancing immune health and potentially protecting against autoimmune conditions like T1D.
The mice that received inulin also demonstrated an interesting change in their gut health, showcasing an increase in beneficial bacteria like Bifidobacterium and Akkermansia muciniphila, as well as higher levels of butyrate, a short-chain fatty acid crucial for gut health. This improved gut microbiota seemed to support regulatory T cells, which play an important role in immune regulation.
Specifically, we noted that inulin helped recruit these regulatory T cells into the pancreas, a site critical for managing the immune response in diabetes. This recruitment depended on a specific pathway involving something known as CCR4. When we looked at mice lacking this CCR4 receptor, the beneficial effects of inulin were significantly reduced, highlighting its importance.
Overall, these findings suggest that inulin could be a promising nutritional strategy for enhancing immune health and potentially protecting against autoimmune conditions like T1D.
Read More
9
Probiotics may aid rheumatoid arthritis
The Impacts of and to Promote In Vitro Anti-Inflammatory Profile of RA-Macrophages.
High relevance to autoimmune treatment
We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Read More
9
LC-STH-13 counters lupus effects
LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway.
High relevance, promising findings
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models.
Study shows viable celiac treatment potential.
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
Read More
9
Probiotics may aid IBD recovery
The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics.
Study shows strong probiotic effects.
We explored the effectiveness of probiotics in treating inflammatory bowel disease (IBD) using a novel Gut-Ex-Vivo System (GEVS). Through careful examination, we found that probiotics notably counteracted the negative effects of colon inflammation caused by DNBS in mice.
Our results revealed that probiotics could significantly help restore gut health by promoting the remission of IBD symptoms. This innovative method presents a promising avenue for future research into IBD therapies while also being kind to animal subjects.
Our results revealed that probiotics could significantly help restore gut health by promoting the remission of IBD symptoms. This innovative method presents a promising avenue for future research into IBD therapies while also being kind to animal subjects.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.1
8.3
Improved digestion
Good probiotics—my bowel movements improved, and my stomach no longer felt bloated. I was pleased with the results and will order again.
8
Improved flatulence
Effective ~ ~ ~ I purchased these probiotics to alleviate my flatulence and found that they helped. Feeling better now ~ ~ hee hee.
3.8
Unpleasant gastrointestinal sensation
During the intake, I experienced some unpleasant sensations in my gastrointestinal tract, which ceased after finishing the course. I'm unsure if this was related to the probiotics or merely coincidental, but I won't be ordering them again.
