Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 28 Researches
8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
Supplement Facts
Serving Size: One (1) Capsule
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%+
Total Sugars
0 g
**
Incl. 0 g Added Sugars
0%+
Lactobacillus rhamnosus GG
83 mg (20 billion CFUs)
**
Inulin (Chicory root extract)
200 mg
**
Top Medical Research Studies
9
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
9.5
Inulin protects against type 1 diabetes
We explored how inulin, a type of prebiotic fiber, impacts the immune response in the context of type 1 diabetes (T1D) using a specific mouse model. Our findings showed that mice treated with inulin alongside a chemical that induces diabetes, called streptozotocin, did not develop the disease. In fact, these mice had lower blood glucose levels, reduced inflammation in their pancreas, and more balanced insulin levels compared to those not receiving inulin.
The mice that received inulin also demonstrated an interesting change in their gut health, showcasing an increase in beneficial bacteria like Bifidobacterium and Akkermansia muciniphila, as well as higher levels of butyrate, a short-chain fatty acid crucial for gut health. This improved gut microbiota seemed to support regulatory T cells, which play an important role in immune regulation.
Specifically, we noted that inulin helped recruit these regulatory T cells into the pancreas, a site critical for managing the immune response in diabetes. This recruitment depended on a specific pathway involving something known as CCR4. When we looked at mice lacking this CCR4 receptor, the beneficial effects of inulin were significantly reduced, highlighting its importance.
Overall, these findings suggest that inulin could be a promising nutritional strategy for enhancing immune health and potentially protecting against autoimmune conditions like T1D.
The mice that received inulin also demonstrated an interesting change in their gut health, showcasing an increase in beneficial bacteria like Bifidobacterium and Akkermansia muciniphila, as well as higher levels of butyrate, a short-chain fatty acid crucial for gut health. This improved gut microbiota seemed to support regulatory T cells, which play an important role in immune regulation.
Specifically, we noted that inulin helped recruit these regulatory T cells into the pancreas, a site critical for managing the immune response in diabetes. This recruitment depended on a specific pathway involving something known as CCR4. When we looked at mice lacking this CCR4 receptor, the beneficial effects of inulin were significantly reduced, highlighting its importance.
Overall, these findings suggest that inulin could be a promising nutritional strategy for enhancing immune health and potentially protecting against autoimmune conditions like T1D.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
Read More
Most Useful Reviews
9
Improved digestion
Good probiotics—my bowel movements improved, and my stomach no longer felt bloated. I was pleased with the results and will order again.
Read More
6
Improved flatulence
Effective ~ ~ ~ I purchased these probiotics to alleviate my flatulence and found that they helped. Feeling better now ~ ~ hee hee.
Read More
0
Unpleasant gastrointestinal sensation
During the intake, I experienced some unpleasant sensations in my gastrointestinal tract, which ceased after finishing the course. I'm unsure if this was related to the probiotics or merely coincidental, but I won't be ordering them again.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 28 Researches
8
- All Researches
9.5
Inulin protects against type 1 diabetes
We explored how inulin, a type of prebiotic fiber, impacts the immune response in the context of type 1 diabetes (T1D) using a specific mouse model. Our findings showed that mice treated with inulin alongside a chemical that induces diabetes, called streptozotocin, did not develop the disease. In fact, these mice had lower blood glucose levels, reduced inflammation in their pancreas, and more balanced insulin levels compared to those not receiving inulin.
The mice that received inulin also demonstrated an interesting change in their gut health, showcasing an increase in beneficial bacteria like Bifidobacterium and Akkermansia muciniphila, as well as higher levels of butyrate, a short-chain fatty acid crucial for gut health. This improved gut microbiota seemed to support regulatory T cells, which play an important role in immune regulation.
Specifically, we noted that inulin helped recruit these regulatory T cells into the pancreas, a site critical for managing the immune response in diabetes. This recruitment depended on a specific pathway involving something known as CCR4. When we looked at mice lacking this CCR4 receptor, the beneficial effects of inulin were significantly reduced, highlighting its importance.
Overall, these findings suggest that inulin could be a promising nutritional strategy for enhancing immune health and potentially protecting against autoimmune conditions like T1D.
The mice that received inulin also demonstrated an interesting change in their gut health, showcasing an increase in beneficial bacteria like Bifidobacterium and Akkermansia muciniphila, as well as higher levels of butyrate, a short-chain fatty acid crucial for gut health. This improved gut microbiota seemed to support regulatory T cells, which play an important role in immune regulation.
Specifically, we noted that inulin helped recruit these regulatory T cells into the pancreas, a site critical for managing the immune response in diabetes. This recruitment depended on a specific pathway involving something known as CCR4. When we looked at mice lacking this CCR4 receptor, the beneficial effects of inulin were significantly reduced, highlighting its importance.
Overall, these findings suggest that inulin could be a promising nutritional strategy for enhancing immune health and potentially protecting against autoimmune conditions like T1D.
Read More
9
We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Read More
9
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
Read More
9
Lactobacillus rhamnosus mitigates gliadin's effects
We investigated the effects of Lactobacillus rhamnosus GG (LGG) in combating inflammation and cellular changes caused by gliadin in celiac disease models. Our study found that pretreating intestinal cells with LGG postbiotics stopped the activation of harmful pathways linked to gliadin, such as mTOR and NF-κβ. Notably, this protective effect was also observed in more complex models using organoids derived from celiac patients. While these findings are promising, further research is necessary to fully understand LGG’s potential benefits in managing celiac disease.
Read More
9
We explored the effectiveness of probiotics in treating inflammatory bowel disease (IBD) using a novel Gut-Ex-Vivo System (GEVS). Through careful examination, we found that probiotics notably counteracted the negative effects of colon inflammation caused by DNBS in mice.
Our results revealed that probiotics could significantly help restore gut health by promoting the remission of IBD symptoms. This innovative method presents a promising avenue for future research into IBD therapies while also being kind to animal subjects.
Our results revealed that probiotics could significantly help restore gut health by promoting the remission of IBD symptoms. This innovative method presents a promising avenue for future research into IBD therapies while also being kind to animal subjects.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved digestion
Good probiotics—my bowel movements improved, and my stomach no longer felt bloated. I was pleased with the results and will order again.
Read More
6
Improved flatulence
Effective ~ ~ ~ I purchased these probiotics to alleviate my flatulence and found that they helped. Feeling better now ~ ~ hee hee.
Read More
0
Unpleasant gastrointestinal sensation
During the intake, I experienced some unpleasant sensations in my gastrointestinal tract, which ceased after finishing the course. I'm unsure if this was related to the probiotics or merely coincidental, but I won't be ordering them again.
Read More
Frequently Asked Questions
9
Improved digestion
Good probiotics—my bowel movements improved, and my stomach no longer felt bloated. I was pleased with the results and will order again.
6
Improved flatulence
Effective ~ ~ ~ I purchased these probiotics to alleviate my flatulence and found that they helped. Feeling better now ~ ~ hee hee.
0
Unpleasant gastrointestinal sensation
During the intake, I experienced some unpleasant sensations in my gastrointestinal tract, which ceased after finishing the course. I'm unsure if this was related to the probiotics or merely coincidental, but I won't be ordering them again.
9
We examined how probiotics, specifically Lactobacillus rhamnosus, could help with rheumatoid arthritis (RA) symptoms. By isolating monocytes from RA patients and healthy individuals, we created macrophages and tested various treatments.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
Our findings revealed that probiotics encouraged macrophages to adopt a more anti-inflammatory state. They increased beneficial cytokines while lowering inflammatory ones. This suggests a potential role for probiotics in managing RA, showing they might help modulate immune responses and improve symptoms.
9
We explored the effects of probiotic LC-STH-13 on systemic lupus erythematosus (SLE) in MRL/lpr mice. Our study demonstrated that LC-STH-13 significantly decreased harmful autoantibodies and rebalanced specific immune cells.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
We also observed reduced immune cell infiltration in kidney tissue, indicating less inflammation. Furthermore, the probiotic helped restore healthy gut microbiota which gets disrupted by SLE. These findings suggest that LC-STH-13 may offer a novel way to manage lupus by targeting both immune regulation and gut health.
8
We conducted a randomized, double-blind study to evaluate the effects of synbiotics on disease activity in systemic lupus erythematosus (SLE). Fifty patients received either standard therapy with synbiotics, including Lactobacillus rhamnosus, or standard therapy alone for two months.
The results revealed a significant reduction in inflammatory markers and disease activity in the synbiotics group, while the placebo group saw no substantial changes. This suggests that synbiotics may serve as a helpful adjunct to existing treatments for SLE, although more research is necessary to fully understand how they work.
The results revealed a significant reduction in inflammatory markers and disease activity in the synbiotics group, while the placebo group saw no substantial changes. This suggests that synbiotics may serve as a helpful adjunct to existing treatments for SLE, although more research is necessary to fully understand how they work.
References
- Ahmadi P, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Ahmadi-Khorram M, et al. The Impacts of and to Promote In Vitro Anti-Inflammatory Profile of RA-Macrophages. Food Sci Nutr. 2025;13:e70068. 10.1002/fsn3.70068
- Liao W, Zhang X, Jia C, Chen W, Cai Y, et al. LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway. Food Funct. 2025;16:475. 10.1039/d4fo03966a
- Mirfeizi Z, Mahmoudi M, Jokar MH, Sahebari M, Noori E, et al. Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial. J Food Sci. 2024;89:9835. 10.1111/1750-3841.17460
- Javanmardi Z, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Shapouri-Moghaddam A, et al. Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile of macrophages-derived monocytes of newly diagnosed patients with systemic lupus erythematosus. Cell Biochem Funct. 2024;42:e3981. 10.1002/cbf.3981
- Vahidi Z, Saghi E, Mahmoudi M, RezaieYazdi Z, Esmaeili SA, et al. Lactobacillus rhamnosus and Lactobacillus delbrueckii Ameliorate the Expression of miR-125a and miR-146a in Systemic Lupus Erythematosus Patients. Appl Biochem Biotechnol. 2024;196:6330. 10.1007/s12010-023-04827-w
- Hoseinzadeh A, Mahmoudi M, Rafatpanah H, Rezaieyazdi Z, Tavakol Afshari J, et al. A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment. Stem Cell Res Ther. 2023;14:358. 10.1186/s13287-023-03578-z
- Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023;228:152415. 10.1016/j.imbio.2023.152415
- Furone F, Bellomo C, Carpinelli M, Nicoletti M, Hewa-Munasinghege FN, et al. The protective role of GG postbiotic on the alteration of autophagy and inflammation pathways induced by gliadin in intestinal models. Front Med (Lausanne). 2023;10:1085578. 10.3389/fmed.2023.1085578
- Lin H, Lin J, Pan T, Li T, Jiang H, et al. Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction. Cell Death Dis. 2023;14:68. 10.1038/s41419-023-05589-3
- Samani SA, Moloudi MR, Ramezanzadeh R, Abdi M, Nikkhoo B, et al. Oral Administration of Probiotic to Ameliorate Experimental Autoimmune Encephalomyelitis in Mice. Basic Clin Neurosci. 2022;13:35. 10.32598/bcn.2021.1955.1
- Monzani R, Gagliardi M, Clemente N, Saverio V, Pańczyszyn E, et al. The Gut-Ex-Vivo System (GEVS) Is a Dynamic and Versatile Tool for the Study of DNBS-Induced IBD in BALB/C and C57BL/6 Mice, Highlighting the Protective Role of Probiotics. Biology (Basel). 2022;11. 10.3390/biology11111574
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. 10.1016/j.jaci.2021.03.025
- Liu Y, Hoang TK, Taylor CM, Park ES, Freeborn J, et al. and differentially affect gut microbes and metabolites in mice with Treg deficiency. Am J Physiol Gastrointest Liver Physiol. 2021;320:G969. 10.1152/ajpgi.00072.2021
- Fan Z, Yang B, Ross RP, Stanton C, Zhao J, et al. The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats. Food Funct. 2020;11:3681. 10.1039/c9fo02556a
- Khorasani S, Mahmoudi M, Kalantari MR, Lavi Arab F, Esmaeili SA, et al. Amelioration of regulatory T cells by Lactobacillus delbrueckii and Lactobacillus rhamnosus in pristane-induced lupus mice model. J Cell Physiol. 2019;234:9778. 10.1002/jcp.27663
- Mardani F, Mahmoudi M, Esmaeili SA, Khorasani S, Tabasi N, et al. In vivo study: Th1-Th17 reduction in pristane-induced systemic lupus erythematosus mice after treatment with tolerogenic Lactobacillus probiotics. J Cell Physiol. 2018;234:642. 10.1002/jcp.26819
- Li N, Han X, Ruan M, Huang F, Yang L, et al. Prebiotic inulin controls Th17 cells mediated central nervous system autoimmunity through modulating the gut microbiota and short chain fatty acids. Gut Microbes. 2024;16:2402547. 10.1080/19490976.2024.2402547
- Lou Y, Wen X, Song S, Zeng Y, Huang L, et al. Dietary pectin and inulin: A promising adjuvant supplement for collagen-induced arthritis through gut microbiome restoration and CD4 T cell reconstitution. J Nutr Biochem. 2024;133:109699. 10.1016/j.jnutbio.2024.109699
- Hashmi HF, Xuan X, Chen K, Zhang P, Shahab M, et al. Molecular modeling and simulation approaches to characterize potential molecular targets for burdock inulin to instigate protection against autoimmune diseases. Sci Rep. 2024;14:11291. 10.1038/s41598-024-61387-7
- Moleón J, González-Correa C, Miñano S, Robles-Vera I, de la Visitación N, et al. Protective effect of microbiota-derived short chain fatty acids on vascular dysfunction in mice with systemic lupus erythematosus induced by toll like receptor 7 activation. Pharmacol Res. 2023;198:106997. 10.1016/j.phrs.2023.106997
- Guimarães JB, Rodrigues VF, Pereira ÍS, Manso GMDC, Elias-Oliveira J, et al. Inulin prebiotic ameliorates type 1 diabetes dictating regulatory T cell homing via CCR4 to pancreatic islets and butyrogenic gut microbiota in murine model. J Leukoc Biol. 2024;115:483. 10.1093/jleuko/qiad132
- Moleón J, González-Correa C, Robles-Vera I, Miñano S, de la Visitación N, et al. Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study. Gut Microbes. 2023;15:2247053. 10.1080/19490976.2023.2247053
- Lo Conte M, Antonini Cencicchio M, Ulaszewska M, Nobili A, Cosorich I, et al. A diet enriched in omega-3 PUFA and inulin prevents type 1 diabetes by restoring gut barrier integrity and immune homeostasis in NOD mice. Front Immunol. 2022;13:1089987. 10.3389/fimmu.2022.1089987
- Zhang R, Xiao Y, Yan J, Yang W, Wu X, et al. Effects of Berberine Plus Inulin on Diabetes Care in Patients With Latent Autoimmune Diabetes in Adults: Protocol for a Randomized Controlled Trial. Front Endocrinol (Lausanne). 2022;13:876657. 10.3389/fendo.2022.876657
- Zou J, Reddivari L, Shi Z, Li S, Wang Y, et al. Inulin Fermentable Fiber Ameliorates Type I Diabetes via IL22 and Short-Chain Fatty Acids in Experimental Models. Cell Mol Gastroenterol Hepatol. 2021;12:983. 10.1016/j.jcmgh.2021.04.014
- Ho J, Nicolucci AC, Virtanen H, Schick A, Meddings J, et al. Effect of Prebiotic on Microbiota, Intestinal Permeability, and Glycemic Control in Children With Type 1 Diabetes. J Clin Endocrinol Metab. 2019;104:4427. 10.1210/jc.2019-00481
- Chen K, Chen H, Faas MM, de Haan BJ, Li J, et al. Specific inulin-type fructan fibers protect against autoimmune diabetes by modulating gut immunity, barrier function, and microbiota homeostasis. Mol Nutr Food Res. 2017;61. 10.1002/mnfr.201601006
- Sitkin SI, Tkachenko EI, Vakhitov TIa, Oreshko LS, Zhigalova TN. [Serum metabolome by gas chromatography-mass spectrometry (GC-MS) in patients with ulcerative colitis and celiac disease]. Eksp Klin Gastroenterol. 2013.
